SMTP 451 4.7.500
access denied, try again later (Microsoft 365)
SMTP 451 4.7.500 to 4.7.699 (shown with an ASxxx tag) is Microsoft 365 temporarily throttling mail from your IP. Microsoft calls it a form of greylisting: the IP's volume rose sharply compared with its history, so mail is deferred while it builds a record. It is temporary and usually clears in a few days.
Should you remove the address?
Keep the address; fix the sending side
Keep it. The restriction is on your IP's recent behaviour.
Soft bounce. Your sending server retries on its own. Investigate only if it keeps failing.
How it appears
451 4.7.500 Server busy. Please try again later from [203.0.113.5]. (AS843)
What causes it
- A sudden increase in volume from an IP Microsoft has little history for.
- A new sending IP or server sending at full volume from day one.
- Mail being sent from the tenant's onmicrosoft.com domain.
How to fix it
In order — try the first one first.
- Let your server keep retrying. Deferred mail is normally accepted as the IP builds history.
- Ramp volume up gradually on new IPs.
- Send from your own domain, not onmicrosoft.com.
- Check that SPF, DKIM and DMARC pass, so reputation builds on an authenticated identity.
Who sends it
Microsoft 365, Exchange Online and Outlook.com.
Microsoft 365
Reply text Access denied, please try again later
Microsoft describes it as suspicious activity detected and sending temporarily restricted for further evaluation.
Common questions
- What does SMTP 451 4.7.500 mean?
- SMTP 451 4.7.500 to 4.7.699 (shown with an ASxxx tag) is Microsoft 365 temporarily throttling mail from your IP. Microsoft calls it a form of greylisting: the IP's volume rose sharply compared with its history, so mail is deferred while it builds a record. It is temporary and usually clears in a few days.
- Should I retry a 451 4.7.500 error?
- Yes, and your sending server does it automatically. 451 is a temporary deferral, and legitimate mail usually arrives on a retry within minutes or hours. Only investigate if it persists across many retries.
- How do I fix SMTP 451 4.7.500?
- Let your server keep retrying. Deferred mail is normally accepted as the IP builds history.
- Is 451 4.7.500 a hard bounce or a soft bounce?
- 451 4.7.500 is a soft bounce. It is temporary, and your sending server retries it automatically. Your sending server retries on its own. Investigate only if it keeps failing.
- Should I remove the address after a 451 4.7.500 bounce?
- Keep it. The restriction is on your IP's recent behaviour.
- Will verifying my list prevent 451 4.7.500?
- Only partly. Temporary deferrals are not about the address, but providers defer senders whose mail looks risky, and a high rate of hard bounces is one of the signals they use.
Clean the list before the next send.
A bounce report only tells you about the addresses you already mailed. The rest of the list has the same kinds of dead mailboxes in it, and each one becomes a hard bounce recorded against your domain the moment you send.
- A real SMTP mailbox check on every row, before anything is sent
- Dead and mistyped addresses split out, so they never reach your sending tool
- Catch-all, disposable and role addresses flagged alongside
Plans from $9 a month, cancel anytime, no contract. Sign in with Google and your first 100 email checks are free, no card. The free tools stay free either way.
More Microsoft replies: every Outlook and Microsoft 365 SMTP error, and the 550 5.7.515 bulk sender rules.
Other 451 replies
Sources
- Source: Microsoft Learn: Email non-delivery reports and SMTP errors in Exchange Online
- Source: RFC 3463: Enhanced Mail System Status Codes
Provider wording is quoted only where the provider publishes it.
Last reviewed 2026-10-22